Substance
ID:130813
Names and Identifiers
IUPAC Traditional name
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate
Synonyms
Biotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMKBiotin-D(OMe)E(OMe)VD(OMe)-FMKBiotin-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone
IUPAC name
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-(6-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}hexanamido)-4-methoxy-4-oxobutanamido]-5-methoxy-5-oxopentanamido]-3-methylbutanamido]-5-fluoro-4-oxopentanoate
Registration numbers
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Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
An inhibitor/probe for Caspases-3. A biotinylated derivative of Caspase-3 inhibitor Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK (Cat. No. FK010) that has been esterified to increase cell permeability. Also inhibits caspase-6, caspase-7, and caspase-10. Can be used to purify caspase-3 from cell lysates. The addition of esterase will enhance inhibitory activity in cell-free systems.
Molecular Spectra
No Data Available
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References
• Nicholson, D.W. et al., Nature, 376:37 (1995).
• Chandler, J. et al., J. Biol. Chem., 273(18):10815 (1998).