Substance
ID:130743
Names and Identifiers
IUPAC name
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
Synonyms
Ac-IEPD-AMCAc-Ile-Glu-Pro-Asp-AMCAc-Ile-Glu-Pro-Asp-7-Amino-4-Methylcoumarin
IUPAC Traditional name
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-methyl-2-oxochromen-7-yl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
Registration numbers
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Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
A fluorogenic substrate for Granzyme B (kcat/Km = 3,330 M-1s-1) that also recognizes granzyme B variants (kcat/Km = 55 M-1s-1 for R192A and kcat/Km = 8.8 M-1s-1 for R192E).
Excitation max.: 360 - 380 nm, Emission max.: 430 - 460 nm
Excitation max.: 360 - 380 nm, Emission max.: 430 - 460 nm
Molecular Spectra
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References
• Harris, J.L. et al., J. Biol. Chem., 273:27364 (1998).
• Thornberry, N.A. et al., Science, 281:1312 (1998).