Substance
ID:130664
Names and Identifiers
IUPAC name
(4S)-4-[(2S)-3-carboxy-2-acetamidopropanamido]-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}butanoic acid
Synonyms
Ac-DEVD-CHOAc-Asp-Glu-Val-Asp-CHOAc-Asp-Glu-Val-Asp-Aldehyde
IUPAC Traditional name
ac-devd-cho
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
A very potent, specific, and reversible inhibitor of caspase-3 (IC50 = 200 pM), caspase-6, caspase-7, caspase-8, and caspase-10.
Molecular Spectra
No Data Available
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References
• Garcia-Calvo, M. et al., J. Biol. Chem., 273:32608 (1998).
• Thornberry, N.A. and Lazebnik, Y. et al., Science, 281:1312 (1998).
• Nicholson, D.W., et al. 1995. Nature 376, 37.
• Nicholson, D.W. et al., Nature Biotech., 14:297 (1996).
• Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.