Substance
ID:130642
Names and Identifiers
Synonyms
Ac-Ile-Glu-Thr-Asp-7-Amino-4-trifluoromethylcoumarinAc-Ile-Glu-Thr-Asp-AFCAc-IGTD-AFC
IUPAC name
(4S)-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
IUPAC Traditional name
(4S)-4-{[(1S,2R)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-hydroxypropyl]carbamoyl}-4-[(2S,3S)-2-acetamido-3-methylpentanamido]butanoic acid
Registration numbers
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Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
A fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Excitation max.: ~400 nm, Emission max.: ~505 nm
Excitation max.: ~400 nm, Emission max.: ~505 nm
Molecular Spectra
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References
• Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Talanian, R.V. et al., J. Biol. Chem., 272:9677 (1997).