Substance
ID:128499
Names and Identifiers
IUPAC name
methyl 3-(2,5-dihydroxyphenyl)prop-2-enoate
Synonyms
Methyl 2,5-dihydroxycinnamateERBSTATIN ANALOG
IUPAC Traditional name
methyl 3-(2,5-dihydroxyphenyl)prop-2-enoate
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Purity
>98%
Safety Information
Storage Condition
Room Temperature (15-30°C)
MSDS Link
Molecule Details
Purity: >98%
Erbstatin is a novel inhibitor of the EGF receptor associated tyrosine kinase1 . It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor associated tyrosine kinase in vitro (IC50 =0.77 μM)2 . Inhibition is competitive with substrate and noncompetitive with ATP.
Erbstatin is a novel inhibitor of the EGF receptor associated tyrosine kinase1 . It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor associated tyrosine kinase in vitro (IC50 =0.77 μM)2 . Inhibition is competitive with substrate and noncompetitive with ATP.
Molecular Spectra
No Data Available
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References
• Imoto, M., et al., Biochem. Int. , 15 : 989 (1987).
• Umezawa, K., et al., FEBS Lett. , 260 : 198 (1990).