Substance
ID:126261
Names and Identifiers
IUPAC Traditional name
6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
IUPAC name
6-(2-{4-[(4-fluorophenyl)(phenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
Synonyms
R590226-[2-[4-[(4-fluorophenyl)phenyl-methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-oneDKIDIACYLGLYCEROL KINASE INHIBITOR I
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Storage Condition
Room Temperature (15-30°C)
Product Information
Certificate of Analysis
Molecule Details
The elevation of diacylglycerol became of major importance when diacylglycerol was shown to stimulate protein kinase C, making this lipid candidate for a second messenger function in the signal transduction system. In intact cells, diacylglycerol is rapidly phosphorylated into phosphatidic acid by diacylglycerol kinase and reverses the protein kinase C activity.
DKI was found to inhibit diacylglycerol kinase. In human red blood cell membranes and in intact platelets, the concentrations needed for half maximal inhibition ranged from 2 to 4x10-6M.
DKI was found to inhibit diacylglycerol kinase. In human red blood cell membranes and in intact platelets, the concentrations needed for half maximal inhibition ranged from 2 to 4x10-6M.
Molecular Spectra
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References
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