Substance
ID:1230
Names and Identifiers
Synonyms
7-Cyanacetylamino-cephalosporansaeureCefacetrileCefacetrilum [inn-latin]Cefacetrilo [inn-spanish]Cephacetrile
Brand Name
CelosporCeltolCristacef
IUPAC Traditional name
cefacetrile
IUPAC name
(6R,7R)-3-[(acetyloxy)methyl]-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Properties
Physical Property
Hydrophobicity(logP)
-0.45 [HANSCH,C ET AL. (1995)]
Molecule Details
Drug Groups
approved
Description
A derivative of 7-aminocephalosporanic acid.
Indication
Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
Pharmacology
Cefacetrile is effective against many Gram-positive bacterial strains and somewhat less effective against Gram-negative species. It works by inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Affected Organisms
Enteric bacteria and other eubacteria
Half Life
1.2 hours
Protein Binding
23 to 38%
Distribution
Vd of 0.2 to 0.5L/.kg
External Links
Molecular Spectra
No Data Available
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References
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