Drug Groups

approved

Description

Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

Indication

For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.

Pharmacology

Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. Bambuterol causes smooth muscle relaxation, resulting in dilation of bronchial passages.

Affected Organisms

Biotransformation

Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase.

Absorption

Bioavailability is 20% following oral administration.

Half Life

13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.

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