Substance
ID:1183
Names and Identifiers
IUPAC name
1-{[3-bromo-2-(2-trifluoromethanesulfonamidophenyl)-1-benzofuran-5-yl]methyl}-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxamide
Synonyms
Saprisartan
IUPAC Traditional name
3-{[3-bromo-2-(2-trifluoromethanesulfonamidophenyl)-1-benzofuran-5-yl]methyl}-5-cyclopropyl-2-ethylimidazole-4-carboxamide
Properties
No Data Available
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Molecule Details
Drug Groups
approved
Description
Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism.(10579749)
Indication
Saprisartan is used in the treatment of hypertension and heart failure.
Pharmacology
By inhibiting the angiotensin II receptor, this drug leades to a decrease in sodium reabsorption and a decrease in vasoconstriction. This has the combined effect of decreasing blood pressure.
Affected Organisms
Humans and other mammals
Molecular Spectra
No Data Available
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References
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