Drug Groups

approved

Description

Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. [PubChem]

Indication

Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia.

Pharmacology

Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia.

Biotransformation

100%

Half Life

51–80 minutes

Elimination

Fecal (40-75%) and renal (30% as unchanged drug and metabolites)

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