Substance
ID:1022
Names and Identifiers
Brand Name
Novo-CloxinNu-Cloxi
Synonyms
CloxacillinCloxacillin Sodium
IUPAC Traditional name
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
IUPAC name
(2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Properties
Physical Property
Solubility
13.9 mg/L
Hydrophobicity(logP)
3
Molecule Details
Drug Groups
approved
Description
A semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]
Indication
Used to treat infections caused by penicillinase-producing staphylococci, including pneumococci, group A beta-hemolytic streptococci, and penicillin G-sensitive and penicillin G-resistant staphylococci.
Pharmacology
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is for use against staphylococci that produce beta-lactamase.
Toxicity
Oral LD50 in rat and mouse is 5000 mg/kg. Intravenous LD50 in rat is 1660 mg/kg. Symptoms of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, and swelling of face, lips, tongue, or throat.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption
Well absorbed from the gastrointestinal tract.
Protein Binding
95%
External Links
Molecular Spectra
No Data Available
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References
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