Substance

ID:1019

Names and Identifiers
Brand Name
GlaucolAntidrasiDaranideDasanideOratrol
Synonyms
DichlorophenamideDiclofenamida [INN-Spanish]DichlofenamideDichlorphenamidDichlorphenamideDiclofenamideDiclofenamidum [INN-Latin]
IUPAC Traditional name
dichlorphenamide
IUPAC name
4,5-dichlorobenzene-1,3-disulfonamide
Registration numbers
PubChem CID
3038
CAS Number
120-97-8
PubChem SID
46505039
Properties
Physical Property
Hydrophobicity(logP)
0.2
Molecule Details
Drug Groups
approved
Description
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]
Indication
For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
Pharmacology
Dichlorphenamide is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
Affected Organisms
Humans and other mammals
Protein Binding
55%
References
• Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. [Pubmed]
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. [Pubmed]
External Links
• [Wikipedia]
• [RxList]
• [Drugs.com]
Molecular Spectra
No Data Available
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References
• Tawil R, McDermott MP, Brown R Jr, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC: Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis. Ann Neurol. 2000 Jan;47(1):46-53. Pubmed
• Okada S, Izumi W, Murai M, Komatsu H, Ishimitsu S: [Diclofenamide Reference Standard (Control 891) of National Institute of Hygienic Sciences] Eisei Shikenjo Hokoku. 1991;(109):148-50. Pubmed
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