CAS 372-48-5|2-fluoropyridine|2-fluoropyridine|2-Fluoropyridine|2-Fluoropyridine 99%|2-氟吡啶|2-Fluoropyridine

InChI=1S/C5H4FN/c6-5-3-1-2-4-7-5/h1-4H

MTAODLNXWYIKSO-UHFFFAOYSA-N

H Acceptors

H Donor

LogD (pH = 5.5)

1.2922058

LogD (pH = 7.4)

1.292206

Log P

1.292206

Molar Refractivity

25.1322

Polarizability

9.114505

Polar Surface Area

12.89

Rotatable Bonds

Lipinski's Rule of Five

true

IUPAC Traditional name

2-Fluoropyridine2-Fluoropyridine 99%2-氟吡啶2-Fluoropyridine

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PC4200

JOC., 53, 2740 (1998): A useful precursor to a large range of 2,3-disubstituted pyridines. Fluorine is activated to nucleophilic displacement & C-3 metallation is possible.

02158145

1 ml = approx. 1.13 g

F15250

Packaging
10, 100 g in glass bottle

47460

Caution
may become deep brown-yellow on storage

• The possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine makes 2-fluoropyridine a useful precursor of a wide range of 2,3-disubstituted pyridines. See, e.g.: J. Org. Chem., 53, 2740 (1988):

Names and Identifiers

IUPAC Traditional name

2-fluoropyridine

IUPAC name

2-fluoropyridine

Synonyms

2-Fluoropyridine2-Fluoropyridine 99%2-氟吡啶2-Fluoropyridine

Registration numbers

PubChem SID

2489477716097327924871024

CAS Number

MDL Number

Beilstein Number

EC Number

PubChem CID

Molecule Details

PC4200

JOC., 53, 2740 (1998): A useful precursor to a large range of 2,3-disubstituted pyridines. Fluorine is activated to nucleophilic displacement & C-3 metallation is possible.

MP Biomedicals

02158145

1 ml = approx. 1.13 g

Sigma Aldrich

F15250

Packaging
10, 100 g in glass bottle

47460

Caution
may become deep brown-yellow on storage

References

PubChem Literature

From Data Sources

Bioactivity

PubChem BioAssay

Australian Hazchem

3YE

EU Hazard Identification Number

UN Number

1993

UN1993

Emergency Response Guidebook(ERG) Number

128

EU Classification

Storage Condition

2-8°C

European Hazard Symbols

Flammable (F)

Irritant (Xi)

RTECS

UT3900000

Risk Statements

R:10-36/37/38

10-36/37/38

Safety Statements

S:9-16-25-26-29

26-36

7-26-33-37-60

Packing Group

III

Hazard Class

GHS Signal Word

Warning

GHS Pictograms

Flammable gases, category 1

Flammable aerosols, categories 1,2

Flammable liquids, categories 1,2,3

Self-reactive substances and mixtures, Types B,C,D,E,F

Pyrophoric liquids, category 1

Pyrophoric solids, category 1

Self-heating substances and mixtures

Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3

Organic peroxides, Types B,C,D,E,F

Acute toxicity (oral, dermal, inhalation), category 4

Skin irritation, category 2

Eye irritation, category 2

Skin sensitisation, category 1

Specific Target Organ Toxicity – Single exposure, category 3

RID/ADR

UN 1993 3/PG 3

German water hazard class

GHS Hazard statements

H226-H315-H319-H335

GHS Precautionary statements

P261-P305+P351+P338

P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A

Personal Protective Equipment

Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Certificate of Analysis

Empirical Formula (Hill Notation)

Molecule

ID:9972