Molecule

05203349 

MP Biomedicals Rare Chemical collection

H3656 

Other Notes
动物结构蛋白（如胶原和弹性蛋白）的天然成分。

H5534 

Other Notes
动物结构蛋白（如胶原和弹性蛋白）的天然成分。
包装
10 mg in autosmp vl
Biochem/physiol Actions
Hydroxyproline (4-hydroxyproline) is a non-proteinogenic amino acid formed by the post-translational hydroxylation of proline. Hydroxyproline is a major component of collagen, where it serves to stabilize the helical structure. Because hydroxyproline is largely restricted to collagen, the measurement of hydroxylproline levels can be used as an indicator of collagen content. Conditions that increase collagen turnover can elevate serum and urine hydroxyproline levels. Urine and serum hydroxyproline levels can be used as a marker for bone resorption.

H54409 

Other Notes
Natural constituent of animal structural proteins such as collagen and elastin.
Packaging
10, 25, 100 g in poly bottle
2.5 g in glass bottle
Application
Versatile reagent for the synthesis of neuroexcitatory kainoids1 and antifungal echinocandins.2 Also employed in the synthesis of chiral ligands for enantioselective ethylation of aldehydes.3

56250 

Other Notes
Natural constituent of animal structural proteins such as collagen and elastin.
Enzymes and intermediates of hydroxyproline degradation1
Biochem/physiol Actions
Trans-4-Hydroxy-L-proline is used as a starting material in the synthesis of (-)-secrinine; the synthesis of prolinol-based nucleotide analogues with N-phosphonomethyl moiety attached to the nitrogen atom of prolinol ring and in asymmetric synthesis of the ABC-ring system of the antitumor antibiotic MPC1001.
Trans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.

H952376 

A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hyd

CHEBI:18095 

An optically active form of 4-hydroxyproline having L-trans-configuration.