Molecule

Drug Groups

approved

Description

Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist.

Indication

For use in the treatment of schizophrenia and depression

Pharmacology

Flupenthixol is an anxiolytic, antidepressive agent and a mood stabilizer. It inhibits the central monoamine receptors, particularly the dopamine D1 and D2 receptors. Therefore, it increases the amount of serotonin and noradrenaline that control mood and thinking, and improves mood.

Toxicity

LD₅₀=300 mk/kg (Oral in mice); LD₅₀=791 mg/kg (Oral in rats); LD₅₀=87 mk/kg (IV in mice); LD₅₀=37 mg/kg (IV in rats)

Affected Organisms

Biotransformation

Mainly hepatic

Absorption

Fairly slow and incomplete after oral administration

Half Life

19 to 39 hours

Protein Binding

Highly bound to plasma proteins (>95%)

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