CAS 75-77-4|TMCS|chlorotrimethylsilane|Trimethylsilyl chloride|chlorotrimethylsilane|Chlorotrimethylsilane 99%|Trimethylchlorosilane|三甲基氯硅烷|Chlorotrimethylsilane|三甲基硅基氯|三甲基氯硅烷溶液...

General Information

Structure

Molecular Formula

C₃H₉ClSi

Molecular Mass

108.64206

Exact Mass

108.0162045

Charge

InChI

InChI=1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChIKey

IJOOHPMOJXWVHK-UHFFFAOYSA-N

Canonic Smiles

C[Si](Cl)(C)C

Isomeric Smiles

[Si](C)(C)(C)Cl

Calculated Properties

JChem

H Acceptors

H Donor

LogD (pH = 5.5)

2.0128

LogD (pH = 7.4)

2.0128

Log P

2.0128

Molar Refractivity

23.4766

Polarizability

11.012379

Polar Surface Area

0.0

Rotatable Bonds

Lipinski's Rule of Five

true

Data Source

Names and Identifiers

Synonyms

TMCSTrimethylsilyl chlorideChlorotrimethylsilane 99%Trimethylchlorosilane三甲基氯硅烷Chlorotrimethylsilane三甲基硅基氯三甲基氯硅烷溶液Silanization solution IV硅烷化溶液 IVChlorotrimethylsilane solution三甲基氯硅烷溶液三甲基氯硅烷/邻二甲苯 1/24 (v/v)Trimethylchlorosilane/o-Xylene 1/24 (v/v)Chlorotrimethylsilane solutionTMS chlorideChlorotrimethylsilaneTMSClDow Corning® Z-1224Trimethylsilyl chloride硅烷 M3Silane M3Chlorotrimethylsilane

IUPAC name

chlorotrimethylsilane

IUPAC Traditional name

chlorotrimethylsilane

Names and Identifiers

Registration numbers

EC Number

MDL Number

Beilstein Number

CAS Number

PubChem CID

Chemspider ID

PubChem SID

24889641248901692489295224863995248883072486402624864097162039327

Wikipedia Title

Trimethylsilyl_chloride

Registration numbers

Properties

Related Proteins

No Data Available

Click here to submit data

Molecular Spectra

No Data Available

Click here to submit data

Molecule Details

Wikipedia

Trimethylsilyl_chloride

Sigma Aldrich

384410

Packaging
100, 800 mL in Sure/Seal™

385433

Packaging
800 mL in Sure/Seal™

C72854

Application
For the preparation of volatile derivatives of a wide range of compounds for GC analysis.
Packaging
100, 500 mL in Sure/Seal™
5 mL in glass bottle
View returnable container options.

386529

Application
Used in Fisher Glycosylation
Packaging
1 L in Sure/Seal™
25, 100 mL in Sure/Seal™

95541

Application
Used in Fisher Glycosylation
Other Notes
Silane M3
prices for bulk quantities on request
Packaging
5 kg in ss drum
500 g in Sure/Seal™

92361

Application
Used in Fisher Glycosylation
Packaging
1 L in glass bottle
100, 250, 500 mL in glass bottle

92360

Other Notes
Silylating agent1,2

85120

General description
Visit our Sensor Applications portal to learn more.
Other Notes
Ready-to-use solution for silanizing microelectrode pipettes by the dip-and-bake method1,2
Legal Information
Selectophore is a trademark of Sigma-Aldrich GmbH

Molecule Details

References

PubChem Literature

From Data Sources

• For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).

• Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ?-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethylsilyl trifluoromethanesulfonate, A12535.

• Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7,424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).

• Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.

• For cleavage of ethers, see Sodium iodide, A15480.

• For further details and reviews, see Appendix 4.

• The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO₂: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.

References

Bioactivity

PubChem BioAssay

Bioactivity

Names and Identifiers

Synonyms

IUPAC name

chlorotrimethylsilane

IUPAC Traditional name

chlorotrimethylsilane

Registration numbers

EC Number

MDL Number

Beilstein Number

CAS Number

PubChem CID

Chemspider ID

PubChem SID

24889641248901692489295224863995248883072486402624864097162039327

Wikipedia Title

Trimethylsilyl_chloride

Molecule Details

Wikipedia

Trimethylsilyl_chloride

Sigma Aldrich

384410

Packaging
100, 800 mL in Sure/Seal™

385433

Packaging
800 mL in Sure/Seal™

C72854

Application
For the preparation of volatile derivatives of a wide range of compounds for GC analysis.
Packaging
100, 500 mL in Sure/Seal™
5 mL in glass bottle
View returnable container options.

386529

Application
Used in Fisher Glycosylation
Packaging
1 L in Sure/Seal™
25, 100 mL in Sure/Seal™

95541

Application
Used in Fisher Glycosylation
Other Notes
Silane M3
prices for bulk quantities on request
Packaging
5 kg in ss drum
500 g in Sure/Seal™

92361

Application
Used in Fisher Glycosylation
Packaging
1 L in glass bottle
100, 250, 500 mL in glass bottle

92360

Other Notes
Silylating agent1,2

85120

References

PubChem Literature

From Data Sources

• For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).

• For cleavage of ethers, see Sodium iodide, A15480.

• For further details and reviews, see Appendix 4.

Bioactivity

PubChem BioAssay

Properties

Molecule

ID:74408