CAS 957-68-6|7-Aminocephalosporanic acid|7β-aminocephalosporanic acid|(6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid|7-ACA|7-Aminocephalosporinic ...

Selleck Chemicals

S2530

Research Area

Description

Infection

Biological Activity

Description

7-Aminocephalosporanic acid is used for synthesis of cephalosporin antibiotics and intermediates.

Targets

IC₅₀

In Vitro

7-Aminocephalosporanic acid is the basic building block used in the synthesis of many important semisynthetic cephalosporin antibiotics. 7-Aminocephalosporanic acid commonly appears as a white or whitish powder, is an important intermediate for the manufacture of the semisynthetic cephalosporin. 7-Aminocephalosporanic acid is an amphoteric compound. ^[1]

In Vivo

Clinical Trials

Features

References

[1] Wang S, et al. Ind Eng Chem Res, 2005, 44 (10), 3783–3787

MP Biomedicals

02150347

Purity: Approx. 98%
Light yellow crystalline powder

Wikipedia

7-ACA

Sigma Aldrich

191140

Packaging
5 g in glass bottle
Application
Potent inhibitor of bacterial (S. aureus) β-lactamase.1

07300

Other Notes
Coupling to Sepharose® 4B for covalent affinity chromatography of penicillin-binding proteins1
Legal Information
Sepharose is a registered trademark of GE Healthcare

TRC

A603415

It is the starting material for semi-synthetic cephalosporins. Obtained by mild acid hydrolysis of cephalosporin C.

References

PubChem Literature

From Data Sources

• Wang S, et al. Ind Eng Chem Res, 2005, 44 (10), 3783–3787

• Park, S., et al.: J. Biosci. Bioeng., 94, 218 (1987)

• Aramori, I., et al.: J. Ferment. Bioeng., 72, 227 (1987)

• Matsuda, A., et al.: J. Bacteriol., 169, 5815 (1987)

• Takimoto, A., et al.: Appl. Microbiol. Biotechnol., 65, 263 (1987)

GHS Pictograms

Respiratory sensitization, category 1

Germ cell mutagenicity, categories 1A,1B,2

Carcinogenicity, categories 1A,1B,2

Reproductive toxicity, categories 1A,1B,2

Specific Target Organ Toxicity – Single exposure, categories 1,2

Specific Target Organ Toxicity – Repeated exposure, categories 1,2

Aspiration Hazard, category 1

Respiratory sensitization, category 1

Germ cell mutagenicity, categories 1A,1B,2

Carcinogenicity, categories 1A,1B,2

Reproductive toxicity, categories 1A,1B,2

Specific Target Organ Toxicity – Single exposure, categories 1,2

Specific Target Organ Toxicity – Repeated exposure, categories 1,2

Aspiration Hazard, category 1

Molecule

ID:73065

Research Area

Biological Activity

References