Other Notes Reactive peptide coupling reagent suitable for α,α-dialkyl amino acids5; Synthesis of depsipeptides6 Packaging 1 g in poly tube 5, 25 g in poly bottle Application Catalyst for: Synthesis of primary amides1 Direct dehydrative phosphonium cross coupling2 Direct arylation3 Pyrrolidide formation by phosphonium salt coupling reagents4 Legal Information PyBroP is a registered trademark of Merck KGaA
References
PubChem Literature
From Data Sources
• Efficient peptide coupling agent for N-methylated amino esters for which coupling with a number of conventional reagents has proved ineffective or slow, and giving superior results to 1H-Benzotriazol-1-yloxytri(1-pyrrolidinyl)phosphonium hexafluorophosphate, B25251, in this type of reaction: J. Org. Chem., 59, 2437 (1994). See Appendix 6.
• Can also be used to activate formamides, e.g. reaction of DMF with primary amines to yield formamidines: Tetrahedron Lett., 40, 5487 (1999).
Corrosive (C)
Irritant (Xi)