A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. [PubChem]
Indication
For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Pharmacology
Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.
Affected Organisms
Humans and other mammals
Elimination
Approximately 70% of the dose is excreted in the urine, mostly as metabolites.
Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder.
References
PubChem Literature
From Data Sources
• Daniotti, S. et al.: Br. J. Pharmacol., 82, 305 (1982)
• Levin, R. et al.: Neurol. Urodyn., 1, 221 (1982)
• Moller, J. et al .: Acta Med. Scand., 184, 201 (1982)
Harmful (Xn)