Molecule

K1890 

Physical form
Supplied as a 1.6 mM, 0.2 μm-filtered solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K252c belongs to the K252 family of compounds, which are general and potent inhibitors of various protein kinases.1 K252c is a protein kinase C inhibitor, weaker than K252b (IC50 of K252c = 214 nM and IC50 of K252b = 38.3 nM).1 K252c is also a weak inhibitor of calcium/calmodulin-activated phosphodiesterase with IC50 values of 297 μM for the brain enzyme.1, K252c expresses potent cytotoxicity against lung cancer A549 cells in vitro with an IC50 of 2.0 μM and against P388, IC50 = 3.2 μM.2, K252c exhibits moderate cytotoxic activity against K562 cells and induces apoptotic responses at 10 μM.3

S3939 

Biochem/physiol Actions
K-252c is a PKC inhibitor active at submicromolar concentrations.

DB08036 

Drug information: experimental