CAS 10418-03-8|Stromba|Stanozolol|Winstrol|Winstrol Depot (intramuscular injection)|2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol|2,17,18-trimethyl-6,7...

General Information

Structure

Molecular Formula

C₂₁H₃₂N₂O

Molecular Mass

328.49158

Exact Mass

328.25146365

Charge

InChI

InChI=1S/C21H32N2O/c1-19-11-13-12-22-23-18(13)10-14(19)4-5-15-16(19)6-8-20(2)17(15)7-9-21(20,3)24/h12,14-17,24H,4-11H2,1-3H3,(H,22,23)

InChIKey

LKAJKIOFIWVMDJ-UHFFFAOYSA-N

Canonic Smiles

CC12Cc3c[nH]nc3CC1CCC1C2CCC2(C1CCC2(C)O)C

Isomeric Smiles

CC12Cc3c[nH]nc3CC1CCC1C2CCC2(C)C1CCC2(C)O

Calculated Properties

JChem

Acid pKa

16.234053

H Acceptors

H Donor

LogD (pH = 5.5)

3.8062527

LogD (pH = 7.4)

3.8072276

Log P

3.80724

Molar Refractivity

96.7977

Polarizability

37.831547

Polar Surface Area

48.91

Rotatable Bonds

Lipinski's Rule of Five

true

ALOGPS 2.1

Log P

4.33

LOG S

-5.28

Solubility (Water)

1.73e-03 g/l

Data Source

Academic Data

Data Source

Names and Identifiers

Synonyms

Stanozolol

Brand Name

StrombaWinstrolWinstrol Depot (intramuscular injection)

IUPAC Traditional name

2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol

IUPAC name

2,17,18-trimethyl-6,7-diazapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4,7-dien-17-ol

Names and Identifiers

Registration numbers

PubChem SID

16096788799443270

PubChem CID

5277

CAS Number

10418-03-8

Registration numbers

Properties

No Data Available

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Related Proteins

No Data Available

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Molecular Spectra

No Data Available

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Molecule Details

DrugBank

DB06718

Drug Groups

approved

Description

Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes.

Indication

Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating C1-inhibitor deficient hereditary angioedema. C1-inhibitor is a protease that inhibits the complement system (part of the innate immune system), a biochemical chain of reactions which assists the body in removing pathogens from the body. Stanozolol may help control attacks of hereditary angioedema. Stanozolol can be administered orally or intramuscularly.

Pharmacology

Stanozolol is a synthetic anabolic-androgenic steroid (AAS), which promotes cell growth (anabolism) and development/maintenance of masculine characteristics (androgenism).

Half Life

24 hours

References

• Guilarte M, Luengo O, Nogueiras C, Labrador-Horrillo M, Munoz E, Lopez A, Cardona V: Acquired angioedema associated with hereditary angioedema due to C1 inhibitor deficiency. J Investig Allergol Clin Immunol. 2008;18(2):126-30. [Pubmed]

• Thevis M, Schanzer W: Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators. Handb Exp Pharmacol. 2010;(195):99-126. [Pubmed]

• Sloane DE, Lee CW, Sheffer AL: Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007 Sep;120(3):654-8. [Pubmed]

External Links

• [Wikipedia]

Molecule Details

References

PubChem Literature

From Data Sources

• Thevis M, Schanzer W: Synthetic anabolic agents: steroids and nonsteroidal selective androgen receptor modulators. Handb Exp Pharmacol. 2010;(195):99-126. Pubmed

• Sloane DE, Lee CW, Sheffer AL: Hereditary angioedema: Safety of long-term stanozolol therapy. J Allergy Clin Immunol. 2007 Sep;120(3):654-8. Pubmed

References

Bioactivity

PubChem BioAssay

Bioactivity

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General Information

Calculated Properties

• RDKit

• JChem

• ALOGPS 2.1

Data Source