Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
Indication
Used as a topical nasal decongestant and vasoconstrictor in dentistry.
Pharmacology
is a sympathomimetic amine used as a vasoconstrictor in local anesthetic solutions. It has pharmacologic activity similar to that of Epinephrine but it is more stable than Epinephrine. In equal concentrations, Levonordefrin is less potent than Epinephrine in raising blood pressure, and as a vasoconstrictor.
A catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry.
References
PubChem Literature
From Data Sources
• Luduena, F.P., et al.: J. Dent. Res., 37, 206 (1958)
• Farrugia, M.T., et al.: J. Pharm. Pharmac., 21, 199 (1969)
Harmful (Xn)