5-Methyltetrahydrofolate is a methylated derivate of tetrahydrofolate. It is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferases (also called methionine synthases).
A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple
References
PubChem Literature
From Data Sources
• Willems, F. et al.: Br. J. Pharmacol., 145, 823 (2004)
• Prinz-Langhebohi, R.: et al., Br. J. Pharmacol., 158, 2014 (2004)
• Wright, A. et al.: Brit, J. Nutrit., 103, 724 (2010)
