ElectrocortinAldocortinAldosteroneAldosterona [inn-spanish]11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-alAldosteronum [inn-latin]11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-alElektrocortin11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-alAldocortene18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione(+)-aldosterone11beta,21-Dihydroxypregn-4-ene-3,18,20-trione11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-alAldocorten18-Oxocorticosterone11beta,21-dihydroxy-3,20-dioxo-4-pregnen-18-alD-aldosterone18-Aldocorticosterone11β,21-Dihydroxypregn-4-ene-3,18,20-trioneAldosterone11β,21-Dihydroxy-3,20-dioxo-4-pregnen-18-alReichstein X
A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [PubChem]
Pharmacology
At the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3?) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
Affected Organisms
Humans and other mammals
References
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Williams JS, Williams GH: 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72.
[Pubmed]
Frequently Asked Questions Live Chat and Frequently Asked Questions are available for this Product. Application The d-isomer of aldosterone is considered to be the biologically active isomer. Biochem/physiol Actions Biologically active aldosterone isomer; a mineralocorticoid produced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorption of Na+. Other Notes Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
Application The d-isomer of aldosterone is considered to be the biologically active isomer. Other Notes Exists as an equilibrium mixture of the aldehyde and the hemiacetal. Sales restrictions may apply
