• N-Acyl-derivatives are cyclized by a variety of reagents, e.g. P2O5, POCl3, PCl5, etc., to derivatives of isoquinoline, in the Bischler-Napieralski synthesis. For a review, see: Org. React., 6, 74 (1951). Similarly, imines can be cyclized to derivatives of tetrahydroisoquinoline in the Pictet-Spengler synthesis. Reviews: Org. React., 6, 151 (1951); Adv. Het. Chem., 3, 79 (1964); Heterocycles, 3, 223 (1975); 39, 903 (1994).
Corrosive (C)
Harmful (X)