Molecule

Drug Groups

approved

Description

A phenothiazine used as an antipsychotic agent and as an antiemetic. [PubChem]

Indication

Used mainly in the management of psychoses. Also used to control nausea and vomiting.

Pharmacology

Triflupromazine is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists. Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. It reduces anxiety, emotional withdrawal, hallucinations, disorganized thoughts, blunted mood, and suspiciousness. Triflupromazine is used particularly to control violent behavior during acute episodes of psychotic disorders. It can also be used to control severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Triflupromazine acts on the central nervous system.

Toxicity

Symptoms of overdose include agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, and restlessness.

Affected Organisms

Biotransformation

Hepatic.

Absorption

Absorption may be erratic and peak plasma concentrations show large interindividual differences.

Protein Binding

Very high (90% or more).

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