Brimonidine is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. [Wikipedia]
Indication
For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Pharmacology
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow.
Toxicity
Oral LD50 is 50 mg/kg in mice and 100 mg/kg in rats.
Affected Organisms
Humans and other mammals
Biotransformation
Metabolized primarily by the liver.
Absorption
Minimal systemic absorption occurs after ocular insertion.
Half Life
2 hours
Elimination
It is metabolized primarily by the liver. Urinary excretion is the major route of elimination of the drug and its metabolites.
Toxic (T)