CAS 56-40-6|CAS 21931-03-3|CAS 6055-72-7|glycine|Glycocoll|Gyn-Hydralin|Gly|Aciport|Glycine|2-Aminoacetic acid|Glicoamin|2-aminoacetic acid|GLYCINE, USP GRADE|GLYCINE, ELECTROPHORESIS GRADE|Aminoace...

General Information

Structure

Molecular Formula

C₂H₅NO₂

Molecular Mass

75.0666

Exact Mass

75.03202841

Charge

0

InChI

InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChIKey

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Canonic Smiles

NCC(=O)O

Isomeric Smiles

OC(=O)CN

Calculated Properties

JChem

LogD (pH = 7.4)

-3.42

LogD (pH = 5.5)

-3.41

Log P

-3.41

Rotatable Bonds

1

H Donor

2

H Acceptors

3

Lipinski's Rule of Five

true

Acid pKa

2.31

Polar Surface Area

63.32

Polarizability

6.65

Molar Refractivity

16.00

LOG S

0.66

Data Source

Academic Data

750

Data Source

Names and Identifiers

IUPAC Traditional name

glycine

Brand Name

GlycocollGyn-HydralinAciportGlicoaminGlycolixirPadilGlycosthene

Synonyms

GlyGlycine2-Aminoacetic acidGLYCINE, USP GRADEGLYCINE, ELECTROPHORESIS GRADEAminoacetic acidAminoethanoic acidGlycine甘氨酸氨基醋酸Glycine-2-3H乙氨酸氨基乙酸Hampshire GlycineGlycolixirGLYCINE FREE ACIDGlycocollGGLYCINE ACS REAGENT GRADEADENINE HYDROCHLORIDE6-Aminopurine HCl甘氨酸GlycinumAciportGlycostheneNSC 25936PadilNSC 2916NSC 54188H 1Gyn-HydralinGlicoamin2-Aminoacetic acidGlycine solutionAdditive Screening Solution 47/Fluka kit no 78374Glycine 1 M solutionH-Gly-OH甘氨酸, ACSGlycine, ACSH2N-CH2-COOHGlycineGlykokollAminoessigsaeureHglyGlyGlyzinAminoacetic acidGlycocollglycineLeimzuckerGaminoethanoic acidGlycinGLYCINE

IUPAC name

2-aminoacetic acid

Names and Identifiers

Registration numbers

MDL Number

MFCD00008131MFCD00135793

CAS Number

56-40-621931-03-36055-72-7

EC Number

200-272-2231-791-2

Beilstein Number

635782

PubChem SID

2489530624901611248495102486004246508219248951352489535324895355248952101609634942486570124895290248733238145759

Council of Europe Number

Merck Index

Flavis Number

FEMA ID

PubChem CID

Chemspider ID

IUPHAR ligand ID

Unique Ingredient Identifier

Wikipedia Title

CHEMBL

KEGG ID

ATC CODE

DrugBank ID

CHEBI ID

15428CHEBI:5460CHEBI:14344CHEBI:42964CHEBI:10792CHEBI:24368CHEBI:15428

E Number

E640

BRENDA Ligand Database

7230300310813941814593910640738017

MetaboLights Database

MTBLS606MTBLS704MTBLS1103MTBLS2424MTBLS12MTBLS1518MTBLS177MTBLS526MTBLS626MTBLS640MTBLS2538MTBLS349MTBLS516MTBLS5MTBLS1079

BKMS React Database

3801710640714593972310813941830300

Protein Data Bank

5h8q2hu52q4r2vl14kr33zok6dwd6iay5mc46tdq4aqd5a3a1y6h2rca4hof6t9b

SABIO-RK Database

1009912211240115181133103223134488341001837150309861295215034975

PubMed Citation Links

18440992129218991944991019924257157102372223493822401276175826201698632518840508217512721117471616998855220441901715425222079563

UniProt Database

B4TVZ6Q6CRQ9Q6B908O94374Q551B5Q91VR7B2JGE1Q3A8C3Q9D7T1A4QSS5B0UWR3C0ZB49Q086J2Q54JQ1A6ZWD3

Reaxys Registry

635782

ACToR Database

18875-39-325718-94-952955-63-256-40-6

CompTox Database

KNApSAcK Database

MetaCyc Database

SureChEMBL Database

Patent number

US2007212380WO2006002875US2007203089WO2007117927US2002091108WO2007117352US2002082283US2005153963US2007248606WO2007135542WO2007137224US2003078446US2006166895US2008293810

Golm Database

a3744147-4ee3-47f2-a79e-53d47ae7c5bf2dc39d03-5a9e-4b9a-8546-faeacf6d02a283fd9bde-63f9-4661-a457-d1d5929954e4bf269ac2-3537-4599-bb1a-08a39845d191358fa797-eaa0-46ab-8cff-6f93c837330d0a2961a2-082f-45b5-b6d8-3881a0efa012b4821f25-64cd-4af0-9920-b88be73c147d58706c78-b5d0-4afa-b314-12425fdf3b2723d5d4f2-6b81-47a4-889b-5744480cb595fbc29f7d-2268-4233-94d6-8e7a3681530d7db7a38c-bfee-4df0-a826-3e843716fb626153c60b-599d-41cc-9df2-8c8d278c19e5a9d5697a-accf-493f-92b9-09cf82e278ed9b915ee1-6072-46ca-ab61-10e9d816148eb30cbec6-d699-4fc5-b01d-ee4c193235b8772b41e3-6bfd-4404-a6fb-b11466a28061241acfc6-f586-4d71-b2c3-450e7b1bd94f

NMRShiftDB Database

10016953

VirtualMetabolicHuman Database

gly

BioModels Database

BIOMD0000000471BIOMD0000000268BIOMD0000000018BIOMD0000000690BIOMD0000001061BIOMD0000000496BIOMD0000000393BIOMD0000000470BIOMD0000000497BIOMD0000000213BIOMD0000000050BIOMD0000000689BIOMD0000000450BIOMD0000000469BIOMD0000000473

KEGG DRUG Database

D00011

Gmelin ID

1808

Drug Central Database

1,319

EnzymePortal Database

Q03432Q7M3P9P0A441P37051P0A440

HMDB Database

YMDB Database

PDBeChem Database

ECMDB Database

BindingDB Database

Registration numbers

Properties

Pharmacology Properties

rat ... Grin2a(24409)

no known allergens

Properties

Related Proteins

Related Proteins

Molecular Spectra

No Data Available

Click here to submit data

Molecule Details

DrugBank

DB00145

Drug Groups

approved; nutraceutical

Description

A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter. [PubChem]

Indication

Supplemental glycine may have antispastic activity. Very early findings suggest it may also have antipsychotic activity as well as antioxidant and anti-inflammatory activities.

Pharmacology

Helps trigger the release of oxygen to the energy requiring cell-making process; Important in the manufacturing of hormones responsible for a strong immune system.

Toxicity

ORL-RAT LD₅₀ 7930 mg/kg, SCU-RAT LD₅₀ 5200 mg/kg, IVN-RAT LD₅₀ 2600 mg/kg, ORL-MUS LD₅₀ 4920 mg/kg; Doses of 1 gram daily are very well tolerated. Mild gastrointestinal symptoms are infrequently noted. In one study doses of 90 grams daily were also well tole.

Affected Organisms

Humans and other mammals

Biotransformation

Hepatic

Absorption

Absorbed from the small intestine via an active transport mechanism.

External Links

• [Wikipedia]

• [PDRhealth]

Molecule Details

References

PubChem Literature

From Data Sources

• Scott, D., et al.: J. Neurosci., 21, 3063 (2001)

• Papadakis, M., et al.: J. Biol. Chem., 279, 14703 (2001)

• Wolosker, H., et al.: Mol. Neurobiol., 36

• Laube, B., et al.: Neuropharmacology, 47, 994 (2001)

• Chen, P., et al.: Mol. Pharmacol., 67, 1470 (2001)

References

Bioactivity

PubChem BioAssay

Bioactivity

Molecule

ID:31