CAS 75-89-8|CAS 132248-58-9|2,2,2-trifluoroethan-1-ol|trifluoroethanol|Trifluoroethanol|2-Hydroxy-1,1,1-trifluoroethane|(Trifluoromethyl)methanol|2,2,2-Trifluoroethan-1-ol 99%|2,2,2-TRIFLUOROETHANOL...

Trifluoroethanol2-Hydroxy-1,1,1-trifluoroethane(Trifluoromethyl)methanol2,2,2-Trifluoroethan-1-ol 99%2,2,2-TRIFLUOROETHANOLTFE三氟乙基醇2,2,2-TrifluoroethanolTrifluoroethyl alcohol2,2,2-三氟乙醇PERFLUORO-1,1-DIHYDROETHANOL2,2,2-三氟乙醇, NMR grade2,2,2-Trifluoroethanol, NMR grade

Names and Identifiers

Registration numbers

EC Number

MDL Number

Beilstein Number

CAS Number

PubChem SID

2489036724900367248895234650599524859618160966370

DrugBank ID

DB03226

CHEMBL

116675

Wikipedia Title

2,2,2-Trifluoroethanol

PubChem CID

6409

Chemspider ID

21106169

CHEBI ID

42330

Registration numbers

Properties

Related Proteins

No Data Available

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Molecular Spectra

No Data Available

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Molecule Details

DrugBank

DB03226

Drug Groups

experimental

Description

A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications. [PubChem]

MP Biomedicals

02191330

Colorless liquid Purity: >99.5% Specific gravity: 1.38 g/ml b.p. 73.6°C

05213004

MP Biomedicals Rare Chemical collection

05219377

MP Biomedicals Rare Chemical collection

Wikipedia

2,2,2-Trifluoroethanol

Sigma Aldrich

96924

Other Notes
Solvent used for sample preparation in electrophoresis1

326747

Packaging
100 g in glass bottle

T63002

Packaging
25, 100, 500 g in glass bottle
Legal Information
ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Molecule Details

References

PubChem Literature

From Data Sources

• The stereodirecting effect of the MEM group (see 2-Methoxyethoxymethyl chloride, L01050) has been exploited by Percy et al in the formation of a new fluorine-containing acyl anion equivalent: Tetrahedron, 51, 9201 (1995):

• Effective solvent for uncatalyzed epoxidations of alkenes with hydrogen peroxide (caution! 60%): Synlett, 248 (2001). For a review of fluorinated alcohols as solvents for selective and clean reactions, see: Synlett, 18 (2004).

• Useful ionizing solvent, see: Tetrahedron Lett., 2335 (1974), and references therein. Good solvent for oligopeptides with potential as a cosolvent along with proton acceptors such as DMF for peptide coupling reactions: Tetrahedron Lett., 33, 7007 (1992). Compare 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747.

• Claisen or Wittig rearrangements of the derived difluoroallyl alcohols can be used in routes to molecules containing a CF₂ group: Tetrahedron, 51, 11327 (1995); J. Org. Chem., 61, 166 (1996), or to monofluorinated vinylic compounds: Tetrahedron Lett., 37, 5183 (1996).

• Trifluoroethyl esters have also found use as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).

• Reacts with triphenylphosphine dibromide to give the bis(trifluoroethoxy)phosphorane, which converts alcohols to trifluoroethyl ethers, carboxylic acids to trifluoroethyl esters and aldehydes to bis(trifluoroethyl) acetals: J. Org. Chem., 45, 5052 (1980).

References

Bioactivity

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Bioactivity

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Names and Identifiers

• IUPAC name

• IUPAC Traditional name

• Synonyms

Registration numbers

• EC Number

• MDL Number

• Beilstein Number

• CAS Number

• PubChem SID

• DrugBank ID

• CHEMBL

• Wikipedia Title

• PubChem CID

• Chemspider ID

• CHEBI ID

Registration numbers

Properties

• Physical Property

• Safety Information

• Product Information

Related Proteins

Molecular Spectra

Molecule Details

• DrugBank

• MP Biomedicals

• Wikipedia

• Sigma Aldrich

References

• PubChem Literature

• From Data Sources

Bioactivity

• PubChem BioAssay

IUPAC name

2,2,2-trifluoroethan-1-ol

IUPAC Traditional name

trifluoroethanol

Synonyms

MDL Number

MFCD00004672

Beilstein Number

1733203

Wikipedia Title

2,2,2-Trifluoroethanol

Chemspider ID

21106169

DrugBank

DB03226

Drug Groups

experimental

Description

A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications. [PubChem]

MP Biomedicals

02191330

Colorless liquid Purity: >99.5% Specific gravity: 1.38 g/ml b.p. 73.6°C

05213004

MP Biomedicals Rare Chemical collection

05219377

MP Biomedicals Rare Chemical collection

Sigma Aldrich

96924

Other Notes
Solvent used for sample preparation in electrophoresis1

326747

Packaging
100 g in glass bottle

T63002

Packaging
25, 100, 500 g in glass bottle
Legal Information
ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

From Data Sources

• Trifluoroethyl esters have also found use as active esters in peptide coupling; see, for example: J. Chem. Soc., Perkin 1, 2867 (1996).

Physical Property

-44 °C(lit.)

Flash Point

Refractive Index

1.2907

n20/D 1.3(lit.)

1.2900

Density

Vapor Pressure

52 mmHg at 25 °C

70 mmHg ( 25 °C)

Std molar entropy

? J.K^-1.mol^-1

p𝘒ₐ

12.46±0.10 Most Acidic Temp: 25 °C

Apperance

Colorless liquid

Viscosity

0.9 cSt @ 37.78 °C

Std enthalpy of formation

? kJ/mol

Solubility

Miscible in ethanol

Miscible in water

Std enthalpy of combustion

-886.6 kJ/mol

Auto Ignition Point

~896 °F

Vapor Density

3.5 (vs air)

Absorption Wavelength

λ: 260 nm Amax: ≤0.03

λ: 280 nm Amax: ≤0.02

Safety Information

Product Information

9-23-26-36/37/39-60

Flammable gases, category 1

Flammable aerosols, categories 1,2

Flammable liquids, categories 1,2,3

Self-reactive substances and mixtures, Types B,C,D,E,F

Pyrophoric liquids, category 1

Pyrophoric solids, category 1

Self-heating substances and mixtures

Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3

Organic peroxides, Types B,C,D,E,F

Corrosive to metals, category 1

Skin corrosion, categories 1A,1B,1C

Serious eye damage, category 1

Bi: ≤0.1 mg/kg

Mo: ≤0.1 mg/kg

Co: ≤0.02 mg/kg

Li: ≤0.1 mg/kg

Mn: ≤0.02 mg/kg

Ni: ≤0.02 mg/kg

Ba: ≤0.1 mg/kg

Ca: ≤0.5 mg/kg

K: ≤0.5 mg/kg

Zn: ≤0.1 mg/kg

Molecule

ID:2923