Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem]
Indication
Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
Pharmacology
Noradrenaline acts on both alpha-1 and alpha-2 adrenergic receptors to cause vasoconstriction. Its effect in-vitro is often limited to the increasing of blood pressure through antagonising alpha-1 and alpha-2 receptors and causing a resultant increase in systemic vascular resistance.
Toxicity
In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.
Frequently Asked Questions Live Chat and Frequently Asked Questions are available for this Product. Biochem/physiol Actions Adrenergic neurotransmitter Application Norepinephrine is an adrenergic neurotransmitter used in the treatment of hypotension, depression, schizophrenia, and attention deficit/hyperactivity disorders.
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Highly toxic (T+)
Harmful (X)