• Has been used in a synthesis of D-amino acids. The configuration is inverted by conversion of the carboxyl group to the new alkyl chain by reaction with an organolithium reagent to give the ketone, which is deoxygenated by Raney nickel desulfurization of the thioketal, the hydroxymethyl group becoming the new carboxyl group by oxidation with oxygen over a Pt catalyst: J. Am. Chem. Soc., 106, 1095 (1984):
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from glycine or threonine. It is involved in the biosynthesis of purines; pyrimidines; and other amino acids. [PubChem]
Indication
Used as a natural moisturizing agent in some cosmetics and skin care products.
Pharmacology
Serine is classified as a nutritionally non-essential amino acid. Serine is critical for the production of the body's proteins, enzymes and muscle tissue. Serine is needed for the proper metabolism of fats and fatty acids. It also helps in the production of antibodies. Serine is used as a natural moisturizing agent in some cosmetics and skin care products. The main source of essential amino acids is from the diet, non-essential amino acids are normally synthesize by humans and other mammals from common intermediates.
Biochem/physiol Actions Precursor of glycine by serine hydroxymethyltransferase. Other Notes Synthesis of labels for protonation studies by Fourier Transform infrared methods1; Stabilizes mung bean nuclease at pH values below seven2; Amino acid spacing in isotachophoresis on polyacrylamide gel - a critical evaluation3; Growth requirement of various microorganisms4
Analysis Note This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. This CRM is traceable to NIST SRM. Biochem/physiol Actions Precursor of glycine by serine hydroxymethyltransferase. General description Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com. Legal Information TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC
