Biochem/physiol Actions Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.
A potent inhibitor of GSK-3β (IC50=22nM). Also inhibits CDK1 (IC50=180nM) and CDK (IC50=100nM). It reversibly arrests asynchronous HBL-100 cells at G2. It induces apoptosis in the mammary carcinoma cell line MCF-7 (10μM).
A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
References
PubChem Literature
From Data Sources
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• Damiens, E., et al.: Oncogene, 20, 3786 (2001)
• Marko, D., et al.: Br. J. Cancer, 84, 283 (2001)
