• Readily forms ?-lactam derivatives whichare valuable intermediates for the synthesis of a variety of products, including thienamycin: J. Am. Chem. Soc., 102, 6163 (1980); Tetrahedron Lett., 23, 2293 (1982).
Bioactivity
PubChem BioAssay
Properties
Physical Property
Hydrophobicity(logP)
-3.7
Solubility
4.5 g/l
0.5 M HCl: soluble50 mg/mL (with heat)
H2O: soluble5 mg/mL
1 M NaOH: soluble50 mg/mL
1 M HCl: soluble0.5 M at 20 °C, clear, colorless
1 M HCl: soluble100 mg/mL
1 M HCl: soluble50 mg/mL
Melting Point
270-271
270-271°C
>300 °C (dec.)(lit.)
>300°C dec.
Optical Rotation
[α]20/D +25°, c = 8 in 5 M HCl
[α]/D 24.0 to 26.0°, c = 8 in hydrochloric acid (6 N HCl)
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem]
Indication
There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
Pharmacology
L-aspartate is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed.
Toxicity
Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Affected Organisms
Humans and other mammals
Absorption
Absorbed from the small intestine by an active transport process
Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. Packaging 100, 500 g in poly bottle 2 kg in poly bottle 2.5 g in glass bottle
Frequently Asked Questions Live Chat and Frequently Asked Questions are available for this Product. Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation.
Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. L-Aspartic acid is a natural proteinogenic amino acid that may be used in the formulation of cell culture media and in protein and polypeptide synthesis systems and procedures. L-Aspartic acid, an NMDA receptor agonist and non-specific glutamate receptor agonist, is used to differentiate and study the mechanisms of NMDA receptors. Packaging 10 mg in autosmp vl
Analysis Note This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. This CRM is traceable to NIST SRM. Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. General description Certified content by quantitative NMR incl. uncertainty and expiry are given in the certificate.Download your certificate at: http://www.sigma-aldrich.com. Legal Information TraceCERT is a registered trademark of Sigma-Aldrich Co. LLC
Biochem/physiol Actions Principal neurotransmitter for fast synaptic excitation. L-Aspartic acid is a negatively charged carboxyl side-chain containing α amino acid. Aspartic acid is involved in nitrogen metabolism via its inter-conversion to oxaloacetate (OAA). As one of the 22 proteinogenic amino acids L-Asp is incorporated into proteins by translation processes in vitro. L-Aspartic acid is a non-essential amino acid added to cell culture media. L-aspartate supports polyamine biosynthesis.
Irritant (Xi)