CAS 58-60-6|3′-Amino-3′-deoxy-N6,N6-dimethyladenosine|(2R,3S,4R,5S)-4-amino-2-[6-(dimethylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol|Puromycin aminonucleoside|(2R,3S,4R,5S)-4-amino-2-[6-(d...

Molecular Formula

C₁₂H₁₈N₆O₃

Molecular Mass

294.30972

Exact Mass

294.14403847

InChI

InChI=1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1

InChIKey

RYSMHWILUNYBFW-VENHTOENSA-N

Canonic Smiles

OC[C@H]1O[C@H]([C@H]([C@H]1N)O)n1cnc2c1ncnc2N(C)C

Isomeric Smiles

CN(C)c1c2c(ncn1)n(cn2)[C@H]1[C@H]([C@H]([C@H](O1)CO)N)O

JChem

Acid pKa

12.978685

H Acceptors

H Donor

LogD (pH = 5.5)

-4.212318

LogD (pH = 7.4)

-2.7506952

Log P

-1.2608758

Molar Refractivity

74.5813

Polarizability

29.03953

Polar Surface Area

122.55

Rotatable Bonds

Lipinski's Rule of Five

true

Commercial Catalog

Academic Data

Synonyms

3′-Amino-3′-deoxy-N6,N6-dimethyladenosinePuromycin aminonucleoside

IUPAC name

(2R,3S,4R,5S)-4-amino-2-[6-(dimethylamino)-9H-purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol

IUPAC Traditional name

(2R,3S,4R,5S)-4-amino-2-[6-(dimethylamino)purin-9-yl]-5-(hydroxymethyl)oxolan-3-ol

MDL Number

PubChem SID

Beilstein Number

PubChem CID

Safety Information

GHS Hazard statements

H373

GHS Pictograms

Respiratory sensitization, category 1

Germ cell mutagenicity, categories 1A,1B,2

Carcinogenicity, categories 1A,1B,2

Reproductive toxicity, categories 1A,1B,2

Specific Target Organ Toxicity – Single exposure, categories 1,2

Specific Target Organ Toxicity – Repeated exposure, categories 1,2

Aspiration Hazard, category 1

Personal Protective Equipment

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Storage Temperature

2-8°C

German water hazard class

GHS Signal Word

Warning

European Hazard Symbols

Harmful (Xn)

MSDS Link

Download link

Risk Statements

48/22

Product Information

Quality Level

PREMIUM

Empirical Formula (Hill Notation)

C12H18N6O3

Purity

≥99.0% (HPLC)

Pharmacology Properties

Target Organ

Kidney

Physical Property

Solubility

H2O: soluble50 mg/mL, clear, slightly yellow

No Data Available

Click here to submit data

No Data Available

Click here to submit data

Sigma Aldrich

P7130

Biochem/physiol Actions
Puromycin aminonucleoside is used to study human glomerular disease by inducing damage of murine glomerular podocytes1 and is used to study glomerular function and morphology.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

No Data Available

Click here to submit data