CAS 18426-20-5|R(-)-10,11-Dihydroxy-N-n-propylnoraporphine hydrochloride|(9R)-10-propyl-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca...

Molecular Formula

C₁₉H₂₂ClNO₂

Molecular Mass

331.83648

Exact Mass

331.13390663

InChI

InChI=1S/C19H21NO2.ClH/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14;/h3-7,15,21-22H,2,8-11H2,1H3;1H/t15-;/m1./s1

InChIKey

PCOQOGIDTIFQAM-XFULWGLBSA-N

Canonic Smiles

CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O.Cl

Isomeric Smiles

CCCN1CCc2cccc3c2[C@H]1Cc1c3c(c(cc1)O)O.Cl

JChem

Acid pKa

9.313709

H Acceptors

H Donor

LogD (pH = 5.5)

1.181287

LogD (pH = 7.4)

2.938351

Log P

3.6735916

Molar Refractivity

89.2607

Polarizability

35.331387

Polar Surface Area

43.7

Rotatable Bonds

Lipinski's Rule of Five

true

Commercial Catalog

Academic Data

Synonyms

R(-)-10,11-Dihydroxy-N-n-propylnoraporphine hydrochlorideR(-)-Propylnorapomorphine hydrochlorideR(-)-NPA hydrochloride

IUPAC Traditional name

(9R)-10-propyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,13,15-hexaene-3,4-diol hydrochloride

IUPAC name

(9R)-10-propyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,13,15-hexaene-3,4-diol hydrochloride

PubChem SID

PubChem CID

CAS Number

MDL Number

Physical Property

Solubility

alcohol: moderately soluble (Solutions should be freshly prepared.)

H2O: moderately soluble (dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. Solutions should be freshly prepared.)

aqueous base: insoluble

methanol: soluble5-10 mg/mL (Solutions should be freshly prepared)

0.1 M HCl: soluble5-10 mg/mL (Solutions should be freshly prepared)

εmax/273 nm, ethanol 17,400

off-white solid

[α]22/D -70.3°, c = 0.17 in methanol(lit.)

Safety Information

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

2-8°C

Pharmacology Properties

human ... DRD2(1813)

No Data Available

Click here to submit data

No Data Available

Click here to submit data

Sigma Aldrich

D027

Biochem/physiol Actions
Highly potent and selective D2 dopamine receptor agonist.
Caution
Subject to rapid oxidation.

No Data Available

Click here to submit data

Commercial Catalog

Academic Data

Synonyms

R(-)-10,11-Dihydroxy-N-n-propylnoraporphine hydrochlorideR(-)-Propylnorapomorphine hydrochlorideR(-)-NPA hydrochloride

IUPAC Traditional name

(9R)-10-propyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,13,15-hexaene-3,4-diol hydrochloride

IUPAC name

(9R)-10-propyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,13,15-hexaene-3,4-diol hydrochloride

PubChem SID

PubChem CID

CAS Number

MDL Number

D027

Biochem/physiol Actions
Highly potent and selective D2 dopamine receptor agonist.
Caution
Subject to rapid oxidation.

No Data Available

Click here to submit data

Physical Property

Solubility

alcohol: moderately soluble (Solutions should be freshly prepared.)

H2O: moderately soluble (dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. Solutions should be freshly prepared.)

aqueous base: insoluble

methanol: soluble5-10 mg/mL (Solutions should be freshly prepared)

0.1 M HCl: soluble5-10 mg/mL (Solutions should be freshly prepared)

εmax/273 nm, ethanol 17,400

off-white solid

[α]22/D -70.3°, c = 0.17 in methanol(lit.)

Safety Information

Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

2-8°C

Pharmacology Properties

human ... DRD2(1813)

Molecule

ID:131500