CAS 848-75-9|''N''-methyllorazepam|Lormetazepam|lormetazepam|methyl-lorazepam|7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one|Ergocalm|WY 4082|(+/-)-Lormetazepa...

General Information

Structure

Molecular Formula

C₁₆H₁₂Cl₂N₂O₂

Molecular Mass

335.18468

Exact Mass

334.02758299

Charge

InChI

InChI=1S/C16H12Cl2N2O2/c1-20-13-7-6-9(17)8-11(13)14(19-15(21)16(20)22)10-4-2-3-5-12(10)18/h2-8,15,21H,1H3

InChIKey

FJIKWRGCXUCUIG-UHFFFAOYSA-N

Canonic Smiles

Clc1ccc2c(c1)C(=NC(C(=O)N2C)O)c1ccccc1Cl

Isomeric Smiles

Clc1ccccc1C1=NC(C(=O)N(C)c2c1cc(cc2)Cl)O

Calculated Properties

JChem

Acid pKa

10.67647

H Acceptors

H Donor

LogD (pH = 5.5)

3.3913887

LogD (pH = 7.4)

3.3911622

Log P

3.3913915

Molar Refractivity

85.8151

Polarizability

32.86259

Polar Surface Area

52.9

Rotatable Bonds

Lipinski's Rule of Five

true

Data Source

Academic Data

Commercial Catalog

Data Source

Names and Identifiers

Synonyms

''N''-methyllorazepamLormetazepammethyl-lorazepam(+/-)-LormetazepamNoctamid7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-oneErgocalmWY 4082Ro 5-5516MethyllorazepamLorametN-MethyllorazepamNoctamide(RS)-Lormetazepam

IUPAC Traditional name

lormetazepam

IUPAC name

7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Names and Identifiers

Registration numbers

ATC CODE

N05CD06

Wikipedia Title

Lormetazepam

Unique Ingredient Identifier

CHEMBL

CHEBI ID

CAS Number

KEGG ID

PubChem CID

Chemspider ID

PubChem SID

Registration numbers

Properties

Safety Information

Controlled Substance, -20°C Freezer

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Physical Property

Pale Green Solid

Chloroform

Ethyl Acetate

163-168°C

Product Information

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Properties

Related Proteins

No Data Available

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Molecular Spectra

No Data Available

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Molecule Details

Wikipedia

Lormetazepam

TRC

L469930

An analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant).

Molecule Details

References

PubChem Literature

From Data Sources

• Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974)

• Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1974)

• Girkin, R., et al.: Xenobiotica, 10, 401 (1974)

References

Bioactivity

PubChem BioAssay

Bioactivity

Data Source

Academic Data

Commercial Catalog

Names and Identifiers

Synonyms

IUPAC Traditional name

lormetazepam

IUPAC name

7-chloro-5-(2-chlorophenyl)-3-hydroxy-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Registration numbers

ATC CODE

N05CD06

Wikipedia Title

Lormetazepam

Unique Ingredient Identifier

CHEMBL

CHEBI ID

CAS Number

KEGG ID

PubChem CID

Chemspider ID

PubChem SID

Molecule Details

L469930

An analog of Lorazepam (L469850). Sedative, hypnotic.Controlled substance (depressant).

References

PubChem Literature

From Data Sources

• Nudelman, A., et al.: J. Pharma. Sci., 63, 1886 (1974)

• Humpel, M., et al.: Eur. J. Drug Metab. Pharmacokinet., 4, 237 (1974)

• Girkin, R., et al.: Xenobiotica, 10, 401 (1974)

Bioactivity

PubChem BioAssay

Properties

Safety Information

Controlled Substance, -20°C Freezer

Download link

Physical Property

Pale Green Solid

Chloroform

Ethyl Acetate

163-168°C

Product Information

Download link

Molecule

ID:130342