Biochem/physiol Actions Bioactive compound found in ginger (Zingiber officinale) with antioxidant activity,1 which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages.2 It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.3 Other Notes Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. G1046.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Biochem/physiol Actions Bioactive compound found in ginger (Zingiber officinale) with antioxidant activity,1 which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages.2 It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.3
(+)-[6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. (+)-[6]-Gingerol down regulates proinflammatory cytokine release by macrophages. (+)-[6]
References
PubChem Literature
From Data Sources
• Tripathi, S. et al.: J. Surg. Res., 130, 318 (1994)
• Kim, S.O., et al.: Oncogene 24, 2558 (1994)
• Aeschbach, R. et al.: Food Chem. Toxicol., 32, 31 (1994)