Molecule

Drug Groups

illicit; approved

Description

A hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem]

Indication

For the treatment of insomnia.

Pharmacology

Glutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms.

Toxicity

In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.

Affected Organisms

Biotransformation

Hepatic. Glutethimide is almost completely metabolized.

Absorption

Variable

Half Life

10-12 hours

Elimination

glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.

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