Molecule

Drug Groups

approved

Description

A benzodiazepine that acts as a gamma-aminobutyric acid modulator and anti-anxiety agent. [PubChem]

Indication

For the short-term treatment of insomnia (generally 7-10 days).

Pharmacology

Temazepam is a benzodiazepine used as a hypnotic agent in the management of insomnia. Temazepam produces CNS depression at limbic, thalamic, and hypothalamic levels of the CNS. Temazepam increases the affinity of the neurotransmitter gamma-aminobutyric acid (GABA) for GABA receptors by binding to benzodiazepine receptors. Results are sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action.

Affected Organisms

Biotransformation

Hepatic. Temazepam is completely metabolized through conjugation prior to excretion. The major metabolite is the O-conjugate of temazepam (90%).

Absorption

Well absorbed, minimal first-pass metabolism.

Half Life

10-20 hours

Protein Binding

96%

Elimination

Temazepam was completely metabolized through conjugation prior to excretion; 80% to 90% of the dose appeared in the urine.

References

External Links