CAS 15933-59-2|bis(dimethylsilyl)amine|TETRAMETHYL DISILAZANE|bis(dimethylsilyl)amine|1,1,3,3-Tetramethyldisilazane|1,1,3,3-四甲基二硅氮烷|TMDS|Bis(dimethylsilyl)amine|Tetramethyldisilazane|四甲基二...

General Information

Structure

Molecular Formula

C₄H₁₅NSi₂

Molecular Mass

133.3396

Exact Mass

133.07430255

Charge

InChI

InChI=1S/C4H15NSi2/c1-6(2)5-7(3)4/h5-7H,1-4H3

InChIKey

NQCZAYQXPJEPDS-UHFFFAOYSA-N

Canonic Smiles

C[SiH](N[SiH](C)C)C

Isomeric Smiles

C[SiH](C)N[SiH](C)C

Calculated Properties

JChem

H Acceptors

H Donor

LogD (pH = 5.5)

-4.1027784

LogD (pH = 7.4)

-3.7365577

Log P

-0.5031

Molar Refractivity

38.6353

Polarizability

15.48848

Polar Surface Area

12.03

Rotatable Bonds

Lipinski's Rule of Five

true

Data Source

Names and Identifiers

IUPAC name

bis(dimethylsilyl)amine

Synonyms

TETRAMETHYL DISILAZANE1,1,3,3-TetramethyldisilazaneTMDS1,1,3,3-四甲基二硅氮烷Bis(dimethylsilyl)amineTetramethyldisilazane四甲基二硅氮烷

IUPAC Traditional name

bis(dimethylsilyl)amine

Names and Identifiers

Registration numbers

CAS Number

PubChem CID

PubChem SID

EC Number

MDL Number

Beilstein Number

Registration numbers

Properties

Safety Information

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Acute toxicity (oral, dermal, inhalation), category 4

Skin irritation, category 2

Eye irritation, category 2

Skin sensitisation, category 1

Specific Target Organ Toxicity – Single exposure, category 3

Properties

Related Proteins

No Data Available

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Molecular Spectra

No Data Available

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Molecule Details

MP Biomedicals

05225649

MP Biomedicals Rare Chemical collection

Sigma Aldrich

139246

Packaging
10 g in glass bottle

87830

Other Notes
Silylating agent1; Silylation/hydrosilylation of β-hydroxy alkenes to silolanes2,3

Molecule Details

References

PubChem Literature

From Data Sources

• The potassium derivative, formed by reaction with KH in THF, reacts with alkyl halides to give, after hydrolysis, high yields of primary amines, thus providing a convenient alternative to the classical Gabriel method. Other silazanes, including hexamethyldisilazane, give lower yields: Synthesis, 150 (1995):

• Reagent for the preparation (see Appendix 4) of dimethylsilyl (DMS) derivatives, compare Hexamethyldisilazane, A15139. With allylic and homoallylic alcohols, the products can undergo Pt- or Rh-catalyzed intramolecular hydrosilylation, providing a regioselective route to 1,3-diols: J. Am. Chem. Soc., 108, 6090 (1986). For an example of this reaction, see Chlorodimethylsilane, A13113.

References

Bioactivity

PubChem BioAssay

Bioactivity