CAS 5086-74-8|CAS 16595-80-5|CAS 5086-74-8,5036-02-2(freebase)|tetramisole hydrochloride hydrochloride|6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride|Nemicide|(-)-6-phenyl-2,3,5,6-te...

General Information

Structure

Molecular Formula

C₁₁H₁₃ClN₂S

Molecular Mass

240.75232

Exact Mass

240.04879711

Charge

InChI

InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H

InChIKey

LAZPBGZRMVRFKY-UHFFFAOYSA-N

Canonic Smiles

C1CN2C(=NC(C2)c2ccccc2)S1.Cl

Isomeric Smiles

Cl.C1CN2CC(N=C2S1)c1ccccc1

Calculated Properties

JChem

H Acceptors

H Donor

LogD (pH = 5.5)

0.91581506

LogD (pH = 7.4)

2.220205

Log P

2.358227

Molar Refractivity

60.0784

Polarizability

23.02744

Polar Surface Area

15.6

Rotatable Bonds

Lipinski's Rule of Five

true

Data Source

Names and Identifiers

IUPAC Traditional name

tetramisole hydrochloride hydrochloride levamisole hydrochloride

IUPAC name

6-phenyl-2H,3H,5H,6H-imidazo[2,1-b][1,3]thiazole hydrochloride

Synonyms

Nemicide(-)-6-phenyl-2,3,5,6-tetrahydroimidazo[2, 1-b]thiazoleL(-)-2,3,5,6-Tetrahydro-6-phenylimidazo(2,1-b)thiazoleDL-2,3,5,6-Tetrahydro-6-phenylimidazo-[2,1-b]-thiazole hydrochlorideTETRAMISOLELEVAMISOLE HYDROCHLORIDETETRAMISOLE HYDROCHLORIDE, BP(±)-2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑盐酸盐Tetramisole hydrochloride四咪唑盐酸盐(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochlorideTetramisole HCl

Names and Identifiers

Registration numbers

EC Number

225-799-5240-654-6

CAS Number

5086-74-816595-80-55086-74-8,5036-02-2(freebase)

PubChem SID

2427872516210292624870604

Beilstein Number

4358989

MDL Number

MFCD00005536

PubChem CID

68628

Registration numbers

Properties

Physical Property

Melting Point

266-268°C

230-233°C

266-267 °C(lit.)

Pharmacology Properties

Target

Others

Properties

Related Proteins

No Data Available

Click here to submit data

Molecular Spectra

No Data Available

Click here to submit data

Molecule Details

MP Biomedicals

02152119

Hydrochloride
Crystalline
Inhibitor of alkaline phosphatase.

02155228

(L[-]-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole) Hydrochloride
Crystalline Suitable as an inhibitor of various mammalian alkaline phosphatases. Intestinal alkaline phosphatases are only slightly inhibited.

Sigma Aldrich

T1512

Application
Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited.
Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.1
Other Notes
Racemic form of levamisole.

31743

Other Notes
Racemic form of levamisole.
Application
Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.1
Legal Information
VETRANAL is a trademark of Sigma-Aldrich Co. LLC

Molecule Details

References

PubChem Literature

From Data Sources

• Van Belle, H., Biochim. Biophys. Acta, 289: 158, (1972).

References

Bioactivity

PubChem BioAssay

Bioactivity