Substance
ID:449181
Names and Identifiers
IUPAC name
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
Synonyms
YewtaxanAnzataxPaclitaxelTaxol A
IUPAC Traditional name
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl benzoate
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antileukaemic and antineoplastic agent, esp. against melanoma and ovarian tumours
Use limited by low solubility and scarce availability of Taxus brevifolia bark
Biochemical tool extensively used to study cellular shape and function.
Also shown to be active against oomycete fungi
Biological Source
Isol. from the stem bark of Taxus brevifolia and Taxus cuspidata (Taxaceae)
Pharmacology Properties
Mechanism of Action
Interferes with the normal function of microtubule growth by hyper-stabilisation of their structure
Binds to the beta subunit of tubulin
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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